Drug interactions
Eprosartan-hydrochlorothiazide + Hydrocortisone
Severity: Moderate
Eprosartan-hydrochlorothiazide and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and corticosteroids promote potassium loss, so combined use increases the risk of hypokalemia. Low potassium can provoke arrhythmias and muscle weakness, particularly in patients on digoxin or with heart disease.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide action and the mineralocorticoid activity of hydrocortisone.
What to do
Monitor serum potassium and magnesium periodically, especially at the start of therapy or with higher steroid doses. Supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Hydrocortisone?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydrochlorothiazide and corticosteroids promote potassium loss, so combined use increases the risk of hypokalemia. Low potassium can provoke arrhythmias and muscle weakness, particularly in patients on digoxin or with heart disease.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically, especially at the start of therapy or with higher steroid doses. Supplement potassium if needed.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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