Drug interactions
Eprosartan-hydrochlorothiazide + Indapamide
Severity: Moderate
Eprosartan-hydrochlorothiazide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates diuretic therapy. This can cause pronounced hypokalemia, hyponatremia, volume depletion and hypotension, with reduced renal function when an ARB is also present.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Two thiazide-type diuretics act at the distal tubule with additive natriuresis and potassium wasting.
What to do
Avoid combining two thiazide-type diuretics unless clearly intended. If used, monitor sodium, potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Indapamide
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Indapamide?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates diuretic therapy. This can cause pronounced hypokalemia, hyponatremia, volume depletion and hypotension, with reduced renal function when an ARB is also present.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazide-type diuretics unless clearly intended. If used, monitor sodium, potassium, creatinine and blood pressure closely.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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