Drug interactions
Eprosartan-hydrochlorothiazide + Insulin aspart protamine / insulin aspart
Severity: Moderate
Eprosartan-hydrochlorothiazide and Insulin aspart protamine / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may enhance insulin sensitivity and increase the glucose-lowering effect of insulin, occasionally causing hypoglycemia. Hydrochlorothiazide may oppose this by worsening glucose tolerance, so glycemic control can fluctuate.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARB-related improvement in insulin sensitivity combined with thiazide-induced hyperglycemia, producing variable effects on glucose.
What to do
Increase blood glucose monitoring when starting, stopping or adjusting the combination tablet. Adjust the insulin dose according to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan-hydrochlorothiazide and Insulin aspart protamine / insulin aspart, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may enhance insulin sensitivity and increase the glucose-lowering effect of insulin, occasionally causing hypoglycemia. Hydrochlorothiazide may oppose this by worsening glucose tolerance, so glycemic control can fluctuate.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Insulin aspart protamine / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring when starting, stopping or adjusting the combination tablet. Adjust the insulin dose according to readings.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
