Drug interactions
Eprosartan-hydrochlorothiazide + Insulin degludec / insulin aspart
Severity: Moderate
Eprosartan-hydrochlorothiazide and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan may enhance insulin sensitivity and increase hypoglycemia risk, while hydrochlorothiazide can raise blood glucose and reduce insulin effectiveness. The net effect on glycemic control is unpredictable and may change when therapy is altered.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects: ARB-enhanced insulin sensitivity versus thiazide-induced insulin resistance and hypokalemia-related reduced insulin secretion.
What to do
Monitor blood glucose more frequently after starting, stopping or changing doses of the antihypertensive. Adjust insulin doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eprosartan may enhance insulin sensitivity and increase hypoglycemia risk, while hydrochlorothiazide can raise blood glucose and reduce insulin effectiveness. The net effect on glycemic control is unpredictable and may change when therapy is altered.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting, stopping or changing doses of the antihypertensive. Adjust insulin doses accordingly.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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