Drug interactions
Eprosartan-hydrochlorothiazide + Insulin isophane human / insulin regular human
Severity: Moderate
Eprosartan-hydrochlorothiazide and Insulin isophane human / insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can improve insulin sensitivity and increase insulin's glucose-lowering effect, sometimes leading to hypoglycemia. Hydrochlorothiazide in the same tablet may counter this by raising glucose, making control less predictable.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARB-related improvement in insulin sensitivity versus thiazide-induced glucose intolerance.
What to do
Check blood glucose more often when starting or changing the combination and adjust insulin doses as needed. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Insulin isophane human / insulin regular human?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers can improve insulin sensitivity and increase insulin's glucose-lowering effect, sometimes leading to hypoglycemia. Hydrochlorothiazide in the same tablet may counter this by raising glucose, making control less predictable.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Insulin isophane human / insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when starting or changing the combination and adjust insulin doses as needed. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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