Drug interactions
Eprosartan-hydrochlorothiazide + Insulin lispro protamine / insulin lispro
Severity: Moderate
Eprosartan-hydrochlorothiazide and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can improve insulin sensitivity and strengthen the glucose-lowering effect of insulin, sometimes causing hypoglycemia. Hydrochlorothiazide may raise glucose and partly counteract this, so glycemic control can shift.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARB-related enhancement of insulin sensitivity versus thiazide-induced glucose intolerance.
What to do
Monitor blood glucose more frequently when starting, stopping or adjusting the combination. Adjust insulin doses as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers can improve insulin sensitivity and strengthen the glucose-lowering effect of insulin, sometimes causing hypoglycemia. Hydrochlorothiazide may raise glucose and partly counteract this, so glycemic control can shift.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, stopping or adjusting the combination. Adjust insulin doses as required.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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