Drug interactions
Eprosartan-hydrochlorothiazide + Insulin nph
Severity: Moderate
Eprosartan-hydrochlorothiazide and Insulin nph: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan may enhance insulin sensitivity and increase the risk of hypoglycemia with NPH insulin. Hydrochlorothiazide can raise glucose and oppose insulin, so the overall effect on control varies.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARB-related improved insulin sensitivity versus thiazide-induced insulin resistance.
What to do
Increase glucose monitoring when therapy is started or changed and adjust the NPH insulin dose based on results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Insulin nph?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eprosartan may enhance insulin sensitivity and increase the risk of hypoglycemia with NPH insulin. Hydrochlorothiazide can raise glucose and oppose insulin, so the overall effect on control varies.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Insulin nph?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase glucose monitoring when therapy is started or changed and adjust the NPH insulin dose based on results.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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