Drug interactions
Eprosartan-hydrochlorothiazide + Ketorolac intranasal
Severity: Major
Eprosartan-hydrochlorothiazide and Ketorolac intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically and, like other NSAIDs, can reduce the antihypertensive effect of eprosartan and hydrochlorothiazide. Combined with an ARB and a diuretic it increases the risk of acute kidney injury and hyperkalemia, especially in volume-depleted or elderly patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and natriuresis, which in combination with ARB and diuretic compromises glomerular filtration.
What to do
Avoid in volume-depleted or renally impaired patients and keep ketorolac courses as short as possible. Monitor creatinine, potassium and blood pressure and ensure hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Ketorolac intranasal?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac is absorbed systemically and, like other NSAIDs, can reduce the antihypertensive effect of eprosartan and hydrochlorothiazide. Combined with an ARB and a diuretic it increases the risk of acute kidney injury and hyperkalemia, especially in volume-depleted or elderly patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Ketorolac intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in volume-depleted or renally impaired patients and keep ketorolac courses as short as possible. Monitor creatinine, potassium and blood pressure and ensure hydration.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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