Drug interactions
Eprosartan-hydrochlorothiazide + Ketorolac
Severity: Major
Eprosartan-hydrochlorothiazide and Ketorolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is a potent NSAID with a notable risk of renal toxicity, and together with a thiazide and an ARB the risk of acute kidney injury is considerably increased. It may also blunt blood pressure control and raise potassium.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
Potent prostaglandin synthesis inhibition lowers renal perfusion, which with diuretic volume loss and angiotensin receptor blockade impairs glomerular filtration.
What to do
Avoid in patients with renal impairment or volume depletion and limit ketorolac to the shortest course. Monitor creatinine, potassium and blood pressure, and consider withholding the diuretic or ARB during short-term use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Ketorolac?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac is a potent NSAID with a notable risk of renal toxicity, and together with a thiazide and an ARB the risk of acute kidney injury is considerably increased. It may also blunt blood pressure control and raise potassium.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Ketorolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with renal impairment or volume depletion and limit ketorolac to the shortest course. Monitor creatinine, potassium and blood pressure, and consider withholding the diuretic or ARB during short-term use.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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