Drug interactions
Eprosartan-hydrochlorothiazide + Meclofenamate
Severity: Moderate
Eprosartan-hydrochlorothiazide and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can reduce the antihypertensive and diuretic effects of eprosartan and hydrochlorothiazide. The combination also raises the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, and impairs potassium excretion.
What to do
Monitor blood pressure, creatinine and potassium, and maintain hydration. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Meclofenamate?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can reduce the antihypertensive and diuretic effects of eprosartan and hydrochlorothiazide. The combination also raises the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, and maintain hydration. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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