Drug interactions
Eprosartan-hydrochlorothiazide + Methyclothiazide
Severity: Moderate
Eprosartan-hydrochlorothiazide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyclothiazide is a second thiazide diuretic, so combining it with a hydrochlorothiazide-containing product duplicates therapy. This adds to electrolyte disturbances such as hypokalemia, hyponatremia and hypomagnesemia, as well as volume depletion and hyperuricemia.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Therapeutic duplication of thiazide diuretics with additive renal sodium, potassium and magnesium loss.
What to do
Avoid using two thiazides together and discontinue one. If unavoidable, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan-hydrochlorothiazide and Methyclothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Methyclothiazide?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methyclothiazide is a second thiazide diuretic, so combining it with a hydrochlorothiazide-containing product duplicates therapy. This adds to electrolyte disturbances such as hypokalemia, hyponatremia and hypomagnesemia, as well as volume depletion and hyperuricemia.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together and discontinue one. If unavoidable, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
