Drug interactions
Eprosartan-hydrochlorothiazide + Mycophenolate
Severity: Minor
Eprosartan-hydrochlorothiazide and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with the mycophenolic acid glucuronide metabolite for renal tubular secretion and could raise its levels. The clinical consequence is uncertain but may include increased mycophenolate effects or toxicity.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition between thiazide and mycophenolic acid glucuronide for renal tubular anionic secretion.
What to do
Monitor for signs of mycophenolate toxicity such as cytopenias and gastrointestinal effects, and check blood counts periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Mycophenolate?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may compete with the mycophenolic acid glucuronide metabolite for renal tubular secretion and could raise its levels. The clinical consequence is uncertain but may include increased mycophenolate effects or toxicity.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of mycophenolate toxicity such as cytopenias and gastrointestinal effects, and check blood counts periodically.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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