Drug interactions
Eprosartan-hydrochlorothiazide + Nafcillin
Severity: Minor
Eprosartan-hydrochlorothiazide and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and penicillins are both eliminated partly by renal tubular secretion, so competition could in theory raise levels of either. For nafcillin, which is cleared largely by the liver, and for hydrochlorothiazide, any clinical effect is expected to be small.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular organic anion secretion, with limited relevance for nafcillin because of its predominantly biliary elimination.
What to do
No routine adjustment is needed; monitor blood pressure and clinical response if nafcillin is given at high doses or for a prolonged course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Nafcillin?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and penicillins are both eliminated partly by renal tubular secretion, so competition could in theory raise levels of either. For nafcillin, which is cleared largely by the liver, and for hydrochlorothiazide, any clinical effect is expected to be small.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure and clinical response if nafcillin is given at high doses or for a prolonged course.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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