Drug interactions
Eprosartan-hydrochlorothiazide + Noni juice
Severity: Moderate
Eprosartan-hydrochlorothiazide and Noni juice: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Noni juice has a high potassium content, and eprosartan reduces renal potassium excretion, so hyperkalemia is possible, especially in renal impairment. Hydrochlorothiazide lowers potassium and partly offsets this, making the net effect unpredictable.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dietary potassium load combined with angiotensin receptor blockade reducing potassium excretion, partly opposed by thiazide kaliuresis.
What to do
Avoid regular noni juice intake, and monitor serum potassium and renal function if it is consumed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Noni juice?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Noni juice has a high potassium content, and eprosartan reduces renal potassium excretion, so hyperkalemia is possible, especially in renal impairment. Hydrochlorothiazide lowers potassium and partly offsets this, making the net effect unpredictable.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Noni juice?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular noni juice intake, and monitor serum potassium and renal function if it is consumed.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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