Drug interactions
Eprosartan-hydrochlorothiazide + Olmesartan
Severity: Major
Eprosartan-hydrochlorothiazide and Olmesartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two angiotensin receptor blockers provides no added benefit and increases the risk of hypotension, hyperkalemia and renal impairment. The eprosartan component duplicates the olmesartan effect.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Olmesartan belongs to Cardiovascular.
Why it happens
Duplicate blockade of the angiotensin II type 1 receptor, producing additive hypotension, reduced glomerular filtration and potassium retention.
What to do
Avoid combining two ARBs; use only one agent. If dual therapy has occurred, check blood pressure, creatinine and potassium and discontinue one drug.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Olmesartan?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two angiotensin receptor blockers provides no added benefit and increases the risk of hypotension, hyperkalemia and renal impairment. The eprosartan component duplicates the olmesartan effect.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Olmesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ARBs; use only one agent. If dual therapy has occurred, check blood pressure, creatinine and potassium and discontinue one drug.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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