Drug interactions
Eprosartan-hydrochlorothiazide + Parecoxib
Severity: Moderate
Eprosartan-hydrochlorothiazide and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib (a COX-2 inhibitor prodrug) can reduce renal prostaglandin synthesis, which blunts the antihypertensive effect of ARBs and thiazides. Together with a diuretic and an ARB this raises the risk of acute kidney injury, particularly in dehydrated or elderly patients, and may cause hyperkalemia.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal vasodilatory prostaglandins reduces glomerular perfusion and sodium excretion, adding to the effects of angiotensin blockade and diuretic volume depletion.
What to do
Maintain hydration and monitor blood pressure, serum creatinine and potassium after starting parecoxib. Use the lowest effective dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Parecoxib?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib (a COX-2 inhibitor prodrug) can reduce renal prostaglandin synthesis, which blunts the antihypertensive effect of ARBs and thiazides. Together with a diuretic and an ARB this raises the risk of acute kidney injury, particularly in dehydrated or elderly patients, and may cause hyperkalemia.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, serum creatinine and potassium after starting parecoxib. Use the lowest effective dose for the shortest duration.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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