Drug interactions
Eprosartan-hydrochlorothiazide + Penbutolol
Severity: Minor
Eprosartan-hydrochlorothiazide and Penbutolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers and the eprosartan-hydrochlorothiazide combination lower blood pressure by complementary mechanisms, and this combination is commonly used with benefit. Additive hypotension or bradycardia can occur, and beta-blockers may slightly raise potassium. Thiazides and beta-blockers may worsen glucose and lipid control.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic blood pressure lowering, with minor impairment of potassium handling by beta-blockade.
What to do
Monitor blood pressure and heart rate, and check potassium and glucose periodically. Avoid use in pregnancy because of ARB fetal toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Penbutolol?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-blockers and the eprosartan-hydrochlorothiazide combination lower blood pressure by complementary mechanisms, and this combination is commonly used with benefit. Additive hypotension or bradycardia can occur, and beta-blockers may slightly raise potassium. Thiazides and beta-blockers may worsen glucose and lipid control.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Penbutolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and check potassium and glucose periodically. Avoid use in pregnancy because of ARB fetal toxicity.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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