Drug interactions
Eprosartan-hydrochlorothiazide + Pirbuterol
Severity: Minor
Eprosartan-hydrochlorothiazide and Pirbuterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirbuterol, a beta-2 agonist, can lower serum potassium, and hydrochlorothiazide also promotes potassium loss. The combination may cause clinically relevant hypokalemia with arrhythmia risk at higher doses or in susceptible patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Pirbuterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypokalemia from beta-2 mediated intracellular potassium shift and thiazide kaliuresis.
What to do
Monitor serum potassium in patients using frequent or high-dose bronchodilator therapy and supplement potassium if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Pirbuterol?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Pirbuterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pirbuterol, a beta-2 agonist, can lower serum potassium, and hydrochlorothiazide also promotes potassium loss. The combination may cause clinically relevant hypokalemia with arrhythmia risk at higher doses or in susceptible patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Pirbuterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients using frequent or high-dose bronchodilator therapy and supplement potassium if needed.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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