Drug interactions
Eprosartan-hydrochlorothiazide + Potassium citrate / citric acid
Severity: Moderate
Eprosartan-hydrochlorothiazide and Potassium citrate / citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium citrate adds a potassium load, and ARBs reduce potassium excretion, so hyperkalemia may occur. The thiazide partly counteracts this, but patients with renal impairment remain at risk.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced aldosterone-mediated potassium excretion from angiotensin receptor blockade plus exogenous potassium.
What to do
Monitor serum potassium and renal function periodically and reduce the potassium citrate dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Potassium citrate / citric acid?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium citrate adds a potassium load, and ARBs reduce potassium excretion, so hyperkalemia may occur. The thiazide partly counteracts this, but patients with renal impairment remain at risk.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Potassium citrate / citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function periodically and reduce the potassium citrate dose if levels rise.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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