Drug interactions
Eprosartan-hydrochlorothiazide + Salicylates
Severity: Moderate
Eprosartan-hydrochlorothiazide and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-aspirin salicylates can reduce renal prostaglandin synthesis, which may blunt antihypertensive effects and increase the risk of renal impairment and hyperkalemia with an ARB and a diuretic. The effect is generally smaller than with conventional NSAIDs but is more likely at high doses.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition reduces renal perfusion and sodium excretion, adding to ARB and diuretic effects on renal hemodynamics.
What to do
Monitor blood pressure, creatinine and potassium with regular or high-dose salicylate use, and keep the patient well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan-hydrochlorothiazide and Salicylates, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Salicylates?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-aspirin salicylates can reduce renal prostaglandin synthesis, which may blunt antihypertensive effects and increase the risk of renal impairment and hyperkalemia with an ARB and a diuretic. The effect is generally smaller than with conventional NSAIDs but is more likely at high doses.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium with regular or high-dose salicylate use, and keep the patient well hydrated.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
