Drug interactions
Eprosartan-hydrochlorothiazide + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Major
Eprosartan-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations cause fluid and electrolyte shifts and dehydration. With a thiazide and ARB, this raises the risk of acute kidney injury, hypokalemia or hyponatremia, and arrhythmia or seizures.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Bowel-prep fluid loss and electrolyte shifts add to diuretic volume depletion and ARB-impaired renal autoregulation.
What to do
Hold the diuretic and ARB on the day of bowel preparation, ensure hydration, and check electrolytes and creatinine in high-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Osmotic bowel preparations cause fluid and electrolyte shifts and dehydration. With a thiazide and ARB, this raises the risk of acute kidney injury, hypokalemia or hyponatremia, and arrhythmia or seizures.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold the diuretic and ARB on the day of bowel preparation, ensure hydration, and check electrolytes and creatinine in high-risk patients.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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