Drug interactions
Eprosartan-hydrochlorothiazide + Squill
Severity: Major
Eprosartan-hydrochlorothiazide and Squill: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Squill contains cardiac glycosides, and thiazide-induced hypokalemia and hypomagnesemia increase the heart's sensitivity to their toxic effects. Arrhythmias may result.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Squill can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Thiazide-induced potassium and magnesium depletion sensitizes the myocardium to cardiac glycosides.
What to do
Avoid the combination where possible. If used, monitor and correct potassium and magnesium and observe for arrhythmias.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Squill?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Squill can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Squill contains cardiac glycosides, and thiazide-induced hypokalemia and hypomagnesemia increase the heart's sensitivity to their toxic effects. Arrhythmias may result.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Squill?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor and correct potassium and magnesium and observe for arrhythmias.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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