Drug interactions
Eprosartan-hydrochlorothiazide + Sulfasalazine
Severity: Minor
Eprosartan-hydrochlorothiazide and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is not an NSAID with meaningful prostaglandin inhibition at usual doses, so the antihypertensive antagonism described for NSAIDs is not expected. No established interaction with eprosartan or hydrochlorothiazide is recognized; any effect on potassium or renal function is unsupported.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; sulfasalazine does not clinically inhibit renal prostaglandins.
What to do
No specific action is needed beyond routine monitoring of renal function and blood counts during sulfasalazine therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Sulfasalazine?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is not an NSAID with meaningful prostaglandin inhibition at usual doses, so the antihypertensive antagonism described for NSAIDs is not expected. No established interaction with eprosartan or hydrochlorothiazide is recognized; any effect on potassium or renal function is unsupported.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of renal function and blood counts during sulfasalazine therapy.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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