Drug interactions
Eprosartan-hydrochlorothiazide + Temocillin
Severity: Minor
Eprosartan-hydrochlorothiazide and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temocillin is eliminated mainly by the kidneys through tubular secretion, and thiazides may compete for this pathway. Serum levels of either drug could rise modestly, although clinical consequences are poorly documented.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion between the beta-lactam and hydrochlorothiazide.
What to do
No routine change is needed; monitor renal function and adverse effects in patients with renal impairment receiving high-dose temocillin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Temocillin?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temocillin is eliminated mainly by the kidneys through tubular secretion, and thiazides may compete for this pathway. Serum levels of either drug could rise modestly, although clinical consequences are poorly documented.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor renal function and adverse effects in patients with renal impairment receiving high-dose temocillin.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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