Drug interactions
Eprosartan-hydrochlorothiazide + Terbutaline
Severity: Moderate
Eprosartan-hydrochlorothiazide and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline and hydrochlorothiazide both lower serum potassium, and together may cause significant hypokalemia with a risk of arrhythmia, especially with high or repeated terbutaline doses. The eprosartan component tends to raise potassium and may partly offset this.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Beta-2 agonist driven intracellular potassium shift adds to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium, particularly with frequent or high-dose terbutaline use. Replace potassium if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Terbutaline
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Terbutaline?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline and hydrochlorothiazide both lower serum potassium, and together may cause significant hypokalemia with a risk of arrhythmia, especially with high or repeated terbutaline doses. The eprosartan component tends to raise potassium and may partly offset this.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with frequent or high-dose terbutaline use. Replace potassium if levels fall.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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