Drug interactions
Eprosartan-hydrochlorothiazide + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Eprosartan-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-agonists such as vilanterol can lower serum potassium and thiazides also cause potassium loss. The combination may worsen hypokalemia and ECG changes, especially at higher than recommended doses.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 agonist-driven intracellular potassium shift and thiazide renal potassium loss.
What to do
Monitor serum potassium in patients at risk and avoid exceeding the recommended inhaler dose; correct hypokalemia if present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-agonists such as vilanterol can lower serum potassium and thiazides also cause potassium loss. The combination may worsen hypokalemia and ECG changes, especially at higher than recommended doses.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients at risk and avoid exceeding the recommended inhaler dose; correct hypokalemia if present.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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