Drug interactions
Eprosartan-hydrochlorothiazide + Xipamide
Severity: Moderate
Eprosartan-hydrochlorothiazide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic and duplicates the action of hydrochlorothiazide. Combining them increases diuresis, electrolyte loss (hypokalemia, hyponatremia) and the risk of hypotension and renal impairment, with the ARB adding to the volume-related effects.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of distal tubular sodium chloride reabsorption causing excessive diuresis and electrolyte depletion.
What to do
Avoid duplicate thiazide-type therapy; if intentional, monitor electrolytes, renal function and blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Xipamide?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic and duplicates the action of hydrochlorothiazide. Combining them increases diuresis, electrolyte loss (hypokalemia, hyponatremia) and the risk of hypotension and renal impairment, with the ARB adding to the volume-related effects.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide-type therapy; if intentional, monitor electrolytes, renal function and blood pressure closely.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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