Drug interactions
Erdafitinib + Fluorouracil
Severity: Moderate
Erdafitinib and Fluorouracil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluorouracil may inhibit CYP2C9, the main enzyme clearing erdafitinib, potentially raising erdafitinib exposure and its toxicities such as hyperphosphatemia, ocular and skin or nail effects. The clinical significance of fluorouracil as a CYP2C9 inhibitor is modest and mainly established for warfarin.
What this interaction means in plain words
Erdafitinib and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Fluorouracil belongs to Oncology.
Why it happens
Possible inhibition of CYP2C9-mediated erdafitinib metabolism.
What to do
Monitor for erdafitinib adverse reactions such as hyperphosphatemia and ocular symptoms, and reduce the erdafitinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erdafitinib and Fluorouracil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluorouracil
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Fluorouracil?
MediHelp rates the interaction as moderate. Erdafitinib and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluorouracil may inhibit CYP2C9, the main enzyme clearing erdafitinib, potentially raising erdafitinib exposure and its toxicities such as hyperphosphatemia, ocular and skin or nail effects. The clinical significance of fluorouracil as a CYP2C9 inhibitor is modest and mainly established for warfarin.
How serious is the interaction between Erdafitinib and Fluorouracil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erdafitinib adverse reactions such as hyperphosphatemia and ocular symptoms, and reduce the erdafitinib dose if toxicity develops.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
