Drug interactions
Erdafitinib + Hydrocortisone
Severity: Minor
Erdafitinib and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein, and hydrocortisone is a P-gp substrate, so exposure to hydrocortisone may increase modestly. Hydrocortisone has a wide therapeutic index, so the effect is usually of limited clinical importance.
What this interaction means in plain words
Erdafitinib and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Hydrocortisone belongs to Endocrine.
Why it happens
Erdafitinib inhibits intestinal and cellular P-glycoprotein efflux of hydrocortisone.
What to do
No routine change is needed; monitor for corticosteroid excess such as fluid retention or hyperglycemia with prolonged use. If a narrow-therapeutic-index P-gp substrate is also used, separate dosing from erdafitinib by 6 hours.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Hydrocortisone?
MediHelp rates the interaction as minor. Erdafitinib and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib inhibits P-glycoprotein, and hydrocortisone is a P-gp substrate, so exposure to hydrocortisone may increase modestly. Hydrocortisone has a wide therapeutic index, so the effect is usually of limited clinical importance.
How serious is the interaction between Erdafitinib and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for corticosteroid excess such as fluid retention or hyperglycemia with prolonged use. If a narrow-therapeutic-index P-gp substrate is also used, separate dosing from erdafitinib by 6 hours.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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