Drug interactions
Erdafitinib + Idarubicin
Severity: Moderate
Erdafitinib and Idarubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib can inhibit P-glycoprotein, and idarubicin is a P-gp substrate. Higher idarubicin exposure may increase myelosuppression and cardiotoxicity, although clinical data for this pair are limited.
What this interaction means in plain words
Erdafitinib and Idarubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Idarubicin belongs to Oncology.
Why it happens
Erdafitinib inhibits P-gp efflux, which may increase idarubicin absorption and tissue exposure.
What to do
Monitor blood counts and cardiac status closely. Consider separating erdafitinib from idarubicin by at least 6 hours where feasible, per labeling for P-gp substrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erdafitinib and Idarubicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Idarubicin?
MediHelp rates the interaction as moderate. Erdafitinib and Idarubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib can inhibit P-glycoprotein, and idarubicin is a P-gp substrate. Higher idarubicin exposure may increase myelosuppression and cardiotoxicity, although clinical data for this pair are limited.
How serious is the interaction between Erdafitinib and Idarubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status closely. Consider separating erdafitinib from idarubicin by at least 6 hours where feasible, per labeling for P-gp substrates.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
