Drug interactions
Erdafitinib + Isoniazid
Severity: Moderate
Erdafitinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP3A4 and raise erdafitinib exposure, increasing risk of hyperphosphatemia, ocular toxicity and stomatitis.
What this interaction means in plain words
Erdafitinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, which contributes to erdafitinib metabolism.
What to do
Monitor serum phosphate, eye symptoms and mucosal toxicity, and reduce the erdafitinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Isoniazid?
MediHelp rates the interaction as moderate. Erdafitinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may inhibit CYP3A4 and raise erdafitinib exposure, increasing risk of hyperphosphatemia, ocular toxicity and stomatitis.
How serious is the interaction between Erdafitinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum phosphate, eye symptoms and mucosal toxicity, and reduce the erdafitinib dose if toxicity develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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