Drug interactions
Erdafitinib + Metformin
Severity: Moderate
Erdafitinib and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits OCT2 in vitro, which could raise metformin concentrations, since metformin is an OCT2 substrate. Increased metformin exposure may heighten gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Erdafitinib and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Metformin belongs to Endocrine.
Why it happens
Erdafitinib inhibits OCT2-mediated renal secretion of metformin.
What to do
Monitor for metformin adverse effects and glycemic control, and reduce the metformin dose if tolerability is poor. Take extra care in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Metformin?
MediHelp rates the interaction as moderate. Erdafitinib and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits OCT2 in vitro, which could raise metformin concentrations, since metformin is an OCT2 substrate. Increased metformin exposure may heighten gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Erdafitinib and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for metformin adverse effects and glycemic control, and reduce the metformin dose if tolerability is poor. Take extra care in patients with renal impairment.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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