Drug interactions
Erdafitinib + Methotrexate
Severity: Moderate
Erdafitinib and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib can inhibit intestinal and cellular P-glycoprotein, which may raise exposure to methotrexate. Higher methotrexate levels increase the risk of myelosuppression, mucositis and hepatic or renal toxicity.
What this interaction means in plain words
Erdafitinib and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Methotrexate belongs to Oncology.
Why it happens
Erdafitinib inhibits P-glycoprotein efflux transport, potentially reducing methotrexate elimination and increasing absorption.
What to do
Monitor blood counts, liver and renal function and signs of methotrexate toxicity if the two are combined. Consider a methotrexate dose reduction if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Methotrexate?
MediHelp rates the interaction as moderate. Erdafitinib and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib can inhibit intestinal and cellular P-glycoprotein, which may raise exposure to methotrexate. Higher methotrexate levels increase the risk of myelosuppression, mucositis and hepatic or renal toxicity.
How serious is the interaction between Erdafitinib and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver and renal function and signs of methotrexate toxicity if the two are combined. Consider a methotrexate dose reduction if toxicity emerges.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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