Drug interactions
Erdafitinib + Pimozide
Severity: Major
Erdafitinib and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib can alter CYP3A4 activity, with inhibition and induction both described. Pimozide has a narrow therapeutic index, so changes in exposure may cause arrhythmia risk or loss of effect.
What this interaction means in plain words
Erdafitinib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erdafitinib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Erdafitinib modulates CYP3A4 activity, altering pimozide metabolism.
What to do
Avoid the combination where possible. If used, monitor ECG and clinical response and adjust the pimozide dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Pimozide?
MediHelp rates the interaction as major. Erdafitinib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erdafitinib can alter CYP3A4 activity, with inhibition and induction both described. Pimozide has a narrow therapeutic index, so changes in exposure may cause arrhythmia risk or loss of effect.
How serious is the interaction between Erdafitinib and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor ECG and clinical response and adjust the pimozide dose.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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