Drug interactions
Ergoloid mesylates + Naratriptan
Severity: Contraindicated
Ergoloid mesylates and Naratriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on serotonergic and vascular receptors, so additive vasoconstriction is possible. Ergoloid's vasoconstrictor activity is modest, but triptan labeling cautions against ergot-type drugs.
What this interaction means in plain words
Ergoloid mesylates and Naratriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction through serotonin receptor agonism and ergot-derived receptor effects.
What to do
Avoid use together and separate by at least 24 hours. Reconsider the need for ergoloid in patients with migraine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
- Frovatriptan + Naratriptan Contraindicated
Frequently asked questions
Can I take Ergoloid mesylates with Naratriptan?
MediHelp rates the interaction as contraindicated. Ergoloid mesylates and Naratriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs act on serotonergic and vascular receptors, so additive vasoconstriction is possible. Ergoloid's vasoconstrictor activity is modest, but triptan labeling cautions against ergot-type drugs.
How serious is the interaction between Ergoloid mesylates and Naratriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use together and separate by at least 24 hours. Reconsider the need for ergoloid in patients with migraine.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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