Drug interactions
Dihydroergotamine + Naratriptan
Severity: Contraindicated
Dihydroergotamine and Naratriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naratriptan and dihydroergotamine each cause vasoconstriction, and together they may prolong vasospastic reactions. This can cause cardiac, cerebral or peripheral ischemia.
What this interaction means in plain words
Dihydroergotamine and Naratriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive vasoconstriction via 5-HT1B/1D agonism and ergot vascular receptor effects.
What to do
Do not use together and keep at least 24 hours between them. Use one agent per attack.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
- Frovatriptan + Naratriptan Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Naratriptan?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Naratriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Naratriptan and dihydroergotamine each cause vasoconstriction, and together they may prolong vasospastic reactions. This can cause cardiac, cerebral or peripheral ischemia.
How serious is the interaction between Dihydroergotamine and Naratriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together and keep at least 24 hours between them. Use one agent per attack.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Eletriptan. The full list is on the Naratriptan page.
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