Drug interactions
Ergonovine + Ketoconazole
Severity: Contraindicated
Ergonovine and Ketoconazole: contraindicated interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors can raise ergonovine levels and produce ergotism with severe vasospasm and ischemia. This class interaction is treated as a contraindication.
What this interaction means in plain words
Ergonovine and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Ketoconazole inhibits CYP3A4-mediated metabolism of ergonovine.
What to do
Do not co-administer. Use an alternative uterotonic such as oxytocin when ketoconazole is being taken.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ergonovine with Ketoconazole?
MediHelp rates the interaction as contraindicated. Ergonovine and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Strong CYP3A4 inhibitors can raise ergonovine levels and produce ergotism with severe vasospasm and ischemia. This class interaction is treated as a contraindication.
How serious is the interaction between Ergonovine and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use an alternative uterotonic such as oxytocin when ketoconazole is being taken.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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