Drug interactions
Eribulin + Erythromycin base
Severity: Major
Eribulin and Erythromycin base: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a macrolide with a known risk of QT prolongation and torsades de pointes. Eribulin adds to this effect, increasing the risk of ventricular arrhythmia.
What this interaction means in plain words
Eribulin and Erythromycin base can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation; erythromycin blocks the IKr potassium current.
What to do
Choose a non-QT-prolonging antibiotic when possible. If erythromycin is needed, check ECG and electrolytes and monitor during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Erythromycin base?
MediHelp rates the interaction as major. Eribulin and Erythromycin base can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin is a macrolide with a known risk of QT prolongation and torsades de pointes. Eribulin adds to this effect, increasing the risk of ventricular arrhythmia.
How serious is the interaction between Eribulin and Erythromycin base?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-QT-prolonging antibiotic when possible. If erythromycin is needed, check ECG and electrolytes and monitor during therapy.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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