Drug interactions
Eribulin + Fexinidazole
Severity: Major
Eribulin and Fexinidazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval and its labeling advises avoiding other QT-prolonging drugs. Eribulin also prolongs the QT interval, so the combination raises the risk of arrhythmia.
What this interaction means in plain words
Eribulin and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid combined use when possible. If both are required, monitor ECGs and keep potassium, magnesium and calcium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Fexinidazole?
MediHelp rates the interaction as major. Eribulin and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval and its labeling advises avoiding other QT-prolonging drugs. Eribulin also prolongs the QT interval, so the combination raises the risk of arrhythmia.
How serious is the interaction between Eribulin and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use when possible. If both are required, monitor ECGs and keep potassium, magnesium and calcium normal.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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