Drug interactions
Eribulin + Lithium
Severity: Moderate
Eribulin and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and lithium may add to this effect. The risk is higher with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Eribulin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Lithium belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization leading to QT prolongation.
What to do
Monitor ECG and electrolytes at baseline and periodically. Correct hypokalemia and hypomagnesemia before and during eribulin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Lithium?
MediHelp rates the interaction as moderate. Eribulin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, and lithium may add to this effect. The risk is higher with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Eribulin and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically. Correct hypokalemia and hypomagnesemia before and during eribulin therapy.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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