Drug interactions
Eribulin + Lumefantrine
Severity: Major
Eribulin and Lumefantrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine, given as artemether-lumefantrine, can prolong the QT interval, as can eribulin. Combined use may add to the effect and increase arrhythmia risk.
What this interaction means in plain words
Eribulin and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination when another antimalarial can be used. If treatment is urgent, perform ECG monitoring and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Lumefantrine?
MediHelp rates the interaction as major. Eribulin and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lumefantrine, given as artemether-lumefantrine, can prolong the QT interval, as can eribulin. Combined use may add to the effect and increase arrhythmia risk.
How serious is the interaction between Eribulin and Lumefantrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when another antimalarial can be used. If treatment is urgent, perform ECG monitoring and correct electrolytes.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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