Drug interactions
Eribulin + Procainamide
Severity: Major
Eribulin and Procainamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procainamide is a class IA antiarrhythmic that prolongs QRS and QT and can cause torsades de pointes. Adding eribulin may increase this risk.
What this interaction means in plain words
Eribulin and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Use an alternative antiarrhythmic if possible. If combined, monitor ECG, QTc and electrolytes closely and consider procainamide levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Procainamide?
MediHelp rates the interaction as major. Eribulin and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procainamide is a class IA antiarrhythmic that prolongs QRS and QT and can cause torsades de pointes. Adding eribulin may increase this risk.
How serious is the interaction between Eribulin and Procainamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antiarrhythmic if possible. If combined, monitor ECG, QTc and electrolytes closely and consider procainamide levels.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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