Drug interactions
Eribulin + Protriptyline
Severity: Moderate
Eribulin and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can prolong QT, and tricyclic antidepressants carry arrhythmia risk. Combined use may increase the chance of torsades de pointes.
What this interaction means in plain words
Eribulin and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Check baseline ECG and electrolytes and repeat during therapy. Consider a non-QT-prolonging antidepressant in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Protriptyline?
MediHelp rates the interaction as moderate. Eribulin and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can prolong QT, and tricyclic antidepressants carry arrhythmia risk. Combined use may increase the chance of torsades de pointes.
How serious is the interaction between Eribulin and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and repeat during therapy. Consider a non-QT-prolonging antidepressant in high-risk patients.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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