Drug interactions
Eribulin + Saquinavir
Severity: Major
Eribulin and Saquinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted saquinavir prolongs the QT and PR intervals, and its labeling contraindicates use with certain QT-prolonging drugs. Eribulin may add to the QT effect and increase the risk of torsades de pointes.
What this interaction means in plain words
Eribulin and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Use an alternative antiretroviral if possible. If both are needed, obtain a baseline ECG, monitor QTc and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Saquinavir?
MediHelp rates the interaction as major. Eribulin and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted saquinavir prolongs the QT and PR intervals, and its labeling contraindicates use with certain QT-prolonging drugs. Eribulin may add to the QT effect and increase the risk of torsades de pointes.
How serious is the interaction between Eribulin and Saquinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antiretroviral if possible. If both are needed, obtain a baseline ECG, monitor QTc and correct electrolytes.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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