Drug interactions
Eribulin + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Eribulin and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and vilanterol, a long-acting beta-2 agonist, can add to cardiovascular effects such as tachycardia and QT prolongation. Combined use may raise the risk of ventricular arrhythmias, particularly with electrolyte disturbances. Systemic vilanterol exposure from inhalation is low, so the effect is usually modest.
What this interaction means in plain words
Eribulin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation and beta-adrenergic cardiac stimulation.
What to do
Check ECG and correct potassium and magnesium before and during eribulin therapy in patients using this inhaler. Monitor for palpitations or arrhythmia and review the need for other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Eribulin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, and vilanterol, a long-acting beta-2 agonist, can add to cardiovascular effects such as tachycardia and QT prolongation. Combined use may raise the risk of ventricular arrhythmias, particularly with electrolyte disturbances. Systemic vilanterol exposure from inhalation is low, so the effect is usually modest.
How serious is the interaction between Eribulin and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before and during eribulin therapy in patients using this inhaler. Monitor for palpitations or arrhythmia and review the need for other QT-prolonging drugs.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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