Drug interactions
Eribulin + Venlafaxine
Severity: Moderate
Eribulin and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and venlafaxine may contribute a small additional effect. The combination may raise the risk of arrhythmia, especially with electrolyte abnormalities.
What this interaction means in plain words
Eribulin and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarisation.
What to do
Monitor ECG and correct hypokalaemia and hypomagnesaemia before and during eribulin therapy. Avoid in congenital long QT syndrome or consider an alternative antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Venlafaxine?
MediHelp rates the interaction as moderate. Eribulin and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, and venlafaxine may contribute a small additional effect. The combination may raise the risk of arrhythmia, especially with electrolyte abnormalities.
How serious is the interaction between Eribulin and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct hypokalaemia and hypomagnesaemia before and during eribulin therapy. Avoid in congenital long QT syndrome or consider an alternative antidepressant.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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