Drug interactions
Erlotinib + Fexinidazole
Severity: Moderate
Erlotinib and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may increase exposure to erlotinib, a CYP3A4 substrate. This may increase erlotinib toxicity such as rash, diarrhea and interstitial lung disease.
What this interaction means in plain words
Erlotinib and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of erlotinib by fexinidazole.
What to do
Avoid if an alternative is available. If used together, monitor for erlotinib adverse effects and reduce the dose in 50 mg steps if severe toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Fexinidazole?
MediHelp rates the interaction as moderate. Erlotinib and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may increase exposure to erlotinib, a CYP3A4 substrate. This may increase erlotinib toxicity such as rash, diarrhea and interstitial lung disease.
How serious is the interaction between Erlotinib and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative is available. If used together, monitor for erlotinib adverse effects and reduce the dose in 50 mg steps if severe toxicity occurs.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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