Drug interactions
Erlotinib + Lumefantrine
Severity: Minor
Erlotinib and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is not an established CYP3A4 inducer, and a meaningful reduction in erlotinib exposure over a short antimalarial course is not well supported.
What this interaction means in plain words
Erlotinib and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not firmly established; a minor effect on CYP3A4 has been suggested.
What to do
No adjustment is needed. Monitor clinical response if used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Lumefantrine?
MediHelp rates the interaction as minor. Erlotinib and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is not an established CYP3A4 inducer, and a meaningful reduction in erlotinib exposure over a short antimalarial course is not well supported.
How serious is the interaction between Erlotinib and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Monitor clinical response if used together.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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