Drug interactions
Erlotinib + Nafcillin
Severity: Moderate
Erlotinib and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin can induce CYP3A4 and may lower erlotinib exposure. Reduced exposure could weaken the anticancer effect.
What this interaction means in plain words
Erlotinib and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing erlotinib metabolism.
What to do
Use an alternative antibiotic if feasible. If nafcillin is required, monitor tumor response and consider an erlotinib dose increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Nafcillin?
MediHelp rates the interaction as moderate. Erlotinib and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin can induce CYP3A4 and may lower erlotinib exposure. Reduced exposure could weaken the anticancer effect.
How serious is the interaction between Erlotinib and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if feasible. If nafcillin is required, monitor tumor response and consider an erlotinib dose increase.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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