Drug interactions
Erythromycin + Glecaprevir / pibrentasvir
Severity: Moderate
Erythromycin and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits P-glycoprotein and CYP3A4 and may increase glecaprevir and pibrentasvir concentrations. Glecaprevir and pibrentasvir inhibit P-gp and OATP, which may raise erythromycin exposure. Clinical consequences are generally modest.
What this interaction means in plain words
Erythromycin and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual P-glycoprotein inhibition, plus OATP1B1/3 inhibition by glecaprevir/pibrentasvir.
What to do
Monitor for adverse effects of both drugs, including hepatic enzyme changes and QT effects of erythromycin. Consider an alternative antibiotic if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Erythromycin with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Erythromycin and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits P-glycoprotein and CYP3A4 and may increase glecaprevir and pibrentasvir concentrations. Glecaprevir and pibrentasvir inhibit P-gp and OATP, which may raise erythromycin exposure. Clinical consequences are generally modest.
How serious is the interaction between Erythromycin and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of both drugs, including hepatic enzyme changes and QT effects of erythromycin. Consider an alternative antibiotic if QT risk factors are present.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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